siRNA-Based Gene Silencing
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Course Overview
Workshop Registration End Date :08/29/2025
Program Syllabus
Module 1
About
Small interfering RNAs (siRNAs) have transformed molecular biology by offering precise and effective gene silencing solutions. This 2-day hands-on workshop dives into the foundational principles of RNA interference (RNAi) and guides participants through the process of understanding, designing, and analyzing siRNA molecules using leading bioinformatics tools.
The program is structured to provide clarity on the distinctions between siRNA, miRNA, and shRNA, while introducing RNA secondary structures and prediction tools like RNAfold, Mfold, and RNAstructure. Participants will also gain practical experience with ΔG analysis, structure ensemble generation, and siRNA design using Genscript. This course bridges the gap between theory and application, preparing attendees for careers in molecular biology, therapeutics, and RNA-based drug design.
Module 2
Aim
To equip participants with a comprehensive understanding of RNA interference mechanisms, siRNA biology, and the computational tools used to design effective siRNA molecules for gene silencing in therapeutics and research.
Lead Instructor
Dr. Sarah Chen
PhD in Computational Mechanics from MIT with 15+ years of experience in Industrial AI. Former Lead Data Scientist at Tesla and current advisor to Fortune 500 manufacturing firms.
Limited SeatsClosing Soon
siRNA-Based Gene Silencing
Professional Certification Program
🎥
FormatLive + Recorded
📅
Duration8 Weeks
📜
CertificationVerified
Module 3
Workshop Objectives
- Understand the molecular basis of RNA interference and siRNA.
- Differentiate between siRNA, miRNA, and shRNA and their applications.
- Analyze RNA secondary structures using bioinformatics tools.
- Gain hands-on experience with ΔG interpretation and RNA folding.
- Learn practical siRNA design using Genscript and evaluate for efficiency.
Module 4
Workshop Structure
Module 5
Day 1: siRNA and RNA Structure Fundamentals
- Introduction to RNAi and siRNA
- siRNA vs miRNA vs shRNA
- Applications in therapeutics and gene regulation
- siRNA structure and functional rules
- Off-target effects and GC content
- Introduction to RNA secondary structures
- RNA folding: base pairing, stem-loops, hairpins
- RNA structure formats
Module 6
Day 2: Tools and Hands-On Design
- RNA structure prediction tools:
RNAfold (ViennaRNA), Mfold, RNAstructure - Hands-on:
Free energy (ΔG) interpretation
Structure ensemble generation - Genscript – siRNA design
- Hands-on siRNA sequence design
Module 7
Intended For
- B.Tech / B.Sc / M.Sc / M.Tech graduates or final-year students from Biotechnology, Bioinformatics, Life Sciences, or allied disciplines
- Researchers and industry professionals working in Genomics, Molecular Biology, Pharmaceutical R&D, or related areas
- Anyone interested in Transcriptomics, Computational Biology, or exploring careers in bioinformatics and RNA-based technologies
Module 8
Important Dates
Module 9
Registration Ends
08/29/2025
Indian Standard Timing 6:00 PM
Module 10
Workshop Dates
08/29/2025 to 08/30/2025
Indian Standard Timing 7:00 PM
Module 11
Workshop Outcomes
- Solid foundation in RNAi and gene silencing
- Hands-on expertise with top RNA structure prediction tools
- Capability to design effective siRNAs with reduced off-target effects
- Enhanced understanding of RNA secondary structure and folding
- Confidence to pursue research or job roles in RNA-based biotech
Module 12
We are excited to announce that we now accept payments in over 20 global currencies, in addition to USD. Check out our list to see if your preferred currency is supported. Enjoy the convenience and flexibility of paying in your local currency!
List of Currencies
Fee Structure
Module 16
Industry Professional Fee
INR. 2499
USD. 75
List of Currencies
Module 17
FOR QUERIES, FEEDBACK OR ASSISTANCE
Module 18
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Key Takeaways
- Access to Live Lectures
- Access to Recorded Sessions
- e-Certificate
- Query Solving Post Workshop
Module 19
Future Career Prospects
- RNA Therapeutics Researcher
- siRNA Design Specialist in Biotech Firms
- Bioinformatics Analyst – RNAi-focused projects
- Drug Development Associate – Nucleic Acid Therapies
- Genetic Engineering & CRISPR-based Researcher
- Academic Research in Gene Regulation or RNA Biology
Module 20
Job Opportunities
- Genomics & RNA Therapeutics Companies (e.g., Alnylam, Moderna, Ionis)
- Research Labs (Government & Private)
- Biotech Startups in RNAi or antisense therapies
- Pharma & Clinical Research Organizations (CROs)
- Academic Institutions (as JRF/SRF/PhD/Postdocs)
- Bioinformatics Tool Development Companies
Module 23
Enter the Hall of Fame!
Take your research to the next level!
Publication Opportunity
Potentially earn a place in our coveted Hall of Fame.
Centre of Excellence
Join the esteemed Centre of Excellence.
Networking and Learning
Network with industry leaders, access ongoing learning opportunities.
Hall of Fame
Get your groundbreaking work considered for publication in a prestigious Open Access Journal (worth ₹20,000/USD 1,000).
Achieve excellence and solidify your reputation among the elite!
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Module 24
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