Designing Nanoparticles for Targeted Cancer Therapy

• Explore Nanoparticle Design and Engineering
• Examine Drug Loading and Release Mechanisms
• Characterize Nanoparticle Properties
• Improve the Pharmacokinetics
• Reduce the Systemic Toxicities of Chemotherapies

Module 1: Principles and Designing of Targeted drug-delivery systems (TDDS) for Cancer Therapy
● Overview of nanoparticles and their applications in cancer treatment
● Role of targeted therapy in cancer treatment
● Principles of TDDS design for targeted drug delivery
● Rationale behind design and application of TDDS
● Selection of suitable materials for TDDS
● Surface modifications and functionalization for target-specific interactions

Module 2: Physicochemical characterization, Biocompatibility and Applications of TDDS for Cancer Therapy

● Physicochemical characterization of TDDS
● Efficient drug loading, drug encapsulation and controlled release
● Stability and self-life of drug molecules
● In vitro and in vivo toxicity evaluation of TDDS and drug molecules, undesirable side effects
● Release kinetics and ADME
● Animal model and clinical studies

Module 3: TDDS in the Market, Various Stages of Clinical Translation and Regulatory Aspects

● FDA and the EMA approved TDDS for cancer therapy
● Mechanism of Actions
● Case Studies
● Challenges for TTDS
● Regulatory Pathways

• Undergraduate degree in Chemistry, Biology, Pharmacy, or related fields.
• Professionals in pharmaceuticals, biotechnology, or healthcare sectors.
• Individuals with a background in materials science or medicinal chemistry interested in oncology.

• Enhanced understanding of cancer biology, including the hallmarks of cancer and oncogenic signaling pathways.
• Familiarity with different cancer treatment modalities, such as chemotherapy, radiation therapy, immunotherapy, and targeted therapy.
• Knowledge of the applications of nanotechnology in cancer therapy, particularly the advantages of nanoparticles in drug delivery, imaging, and theranostics.
• Awareness of drug resistance mechanisms in cancer and exploration of strategies to overcome or mitigate resistance through nanoparticle-based therapies.
• Understanding of tumor targeting strategies, including active targeting using ligands or antibodies, passive targeting via the enhanced permeability and retention (EPR) effect, and physicochemical targeting based on tumor-specific characteristics.

• Nanomedicine Scientist
• Oncological Researcher
• Pharmaceutical Developer
• Biotechnological Innovator
• Clinical Trials Specialist
• Healthcare Technology Consultant