AI-Driven CRISPR Guide RNA Design & Off-Target Prediction
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Course Overview
Workshop Registration End Date :09/25/2025
Program Syllabus
Module 1
About
CRISPR-Cas9 has revolutionized genetic engineering, enabling precise editing of DNA. However, one of the challenges in using CRISPR is the potential for off-target effects that can lead to unintended genetic modifications. This workshop focuses on leveraging AI to design optimized guide RNAs that improve the specificity and efficiency of CRISPR-based genome editing. By integrating machine learning algorithms and large-scale genomic data, participants will learn to predict and minimize off-target effects in gene editing experiments.
Over three days, the workshop will cover the fundamentals of CRISPR-Cas9 technology, the design of gRNAs using AI, and methods to predict and validate off-target effects. Hands-on sessions will allow participants to practice designing guide RNAs and running prediction models for off-target identification using AI-based tools.
Module 2
Aim
This workshop aims to explore the application of AI in CRISPR-Cas9 technology, focusing on guide RNA (gRNA) design and off-target prediction. Participants will learn how to utilize AI algorithms to optimize gRNA sequences for precise gene editing and predict potential off-target effects, ensuring the accuracy and efficiency of CRISPR-based therapies.
Lead Instructor
Dr. Sarah Chen
PhD in Computational Mechanics from MIT with 15+ years of experience in Industrial AI. Former Lead Data Scientist at Tesla and current advisor to Fortune 500 manufacturing firms.
Limited SeatsClosing Soon
AI-Driven CRISPR Guide RNA Design & Off-Target Prediction
Professional Certification Program
🎥
FormatLive + Recorded
📅
Duration8 Weeks
📜
CertificationVerified
Module 3
Workshop Objectives
- Understand the fundamentals of CRISPR-Cas9 and its applications in gene editing.
- Learn how AI can be applied to optimize guide RNA design for CRISPR.
- Gain hands-on experience in using AI algorithms to predict off-target effects.
- Explore methods for validating and minimizing off-target effects in CRISPR experiments.
- Understand the implications of off-target effects and how to mitigate them in genome editing.
Module 4
Workshop Structure
Day 1 – CRISPR Fundamentals & AI Opportunities
- CRISPR-Cas9 mechanism and applications
- Guide RNA selection criteria (efficiency, specificity)
- AI’s role in gRNA prediction and off-target scoring
- Case study: DeepCRISPR, CRISPR-Net tools
Day 2 – Practical AI Models for gRNA Design
- Input datasets for AI models (genomic sequences, PAM sites)
- Using AI tools for scoring potential gRNAs
- Live demo: Running a gRNA design using web-based AI platforms
- Limitations and accuracy considerations
Day 3 – From In-Silico Prediction to Lab Validation
- Integrating AI predictions into wet-lab workflows
- Reducing false positives in off-target effects
- Applications in therapeutic genome editing
Capstone Discussion: Designing a CRISPR experiment with AI support
Module 5
Intended For
- Undergraduate/postgraduate degree in Genetics, Biotechnology, Bioinformatics, Molecular Biology, or related fields.
- Professionals in genomic research, molecular biology, gene therapy, and genetic engineering.
- Data scientists and AI/ML engineers interested in applying AI to genetic editing technologies.
- Individuals with a strong interest in CRISPR technology and gene editing applications.
Module 6
Important Dates
Module 7
Registration Ends
09/25/2025
Indian Standard Timing 7:00 PM
Module 8
Workshop Dates
09/25/2025 to 09/27/2025
Indian Standard Timing 8:00 PM
Module 9
Workshop Outcomes
- Knowledge of the CRISPR-Cas9 technology and its applications in gene editing.
- Skills in designing optimized guide RNAs using AI-based tools.
- Ability to predict and assess off-target effects in CRISPR-based experiments.
- Practical experience with predictive modeling and off-target identification methods.
- Understanding of how to minimize off-target effects and increase the precision of gene editing.
Module 10
We are excited to announce that we now accept payments in over 20 global currencies, in addition to USD. Check out our list to see if your preferred currency is supported. Enjoy the convenience and flexibility of paying in your local currency!
List of Currencies
Fee Structure
Module 14
Industry Professional Fee
INR. 2699
USD. 85
List of Currencies
Module 15
FOR QUERIES, FEEDBACK OR ASSISTANCE
Module 16
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Key Takeaways
- Access to Live Lectures
- Access to Recorded Sessions
- e-Certificate
- Query Solving Post Workshop
Module 17
Future Career Prospects
- CRISPR Research Scientist
- Bioinformatics Specialist in Genomic Data Analysis
- AI Specialist for Gene Editing
- Genomic Medicine Consultant
- CRISPR Therapeutics Developer
- Data Scientist in Biotechnology
Module 18
Job Opportunities
- CRISPR/Cas9 Scientist
- AI/ML Specialist for Genomic Data
- Genetic Engineering Consultant
- Bioinformatics Researcher
- Gene Therapy Specialist
Module 21
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Publication Opportunity
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Centre of Excellence
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Networking and Learning
Network with industry leaders, access ongoing learning opportunities.
Hall of Fame
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Achieve excellence and solidify your reputation among the elite!
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Module 22
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